The human microbiome assumes a key part in an extensive variety of host-related procedures and profoundly affects human wellbeing. Near examinations of the human microbiome have uncovered considerable variety in species and quality piece related with an assortment of ailment states yet may miss the mark regarding providing a far reaching understanding of the effect of this minor departure from the group and on the host. A metagenomic frameworks biology computational structure, was introduced which integrates metagenomic information with an in silico frameworks level investigation of metabolic systems. This was finished focusing on the gut microbiome. Placing varieties in quality plenitude with regards to these systems, both quality level and system level topological contrasts related with corpulence and inflammatory entrail sickness (IBD) were distinguished. A special structure for studying the human microbiome, integrating metagenomic information with a frameworks level system investigation was introduced. This metagenomic frameworks biology approach goes past customary relative investigation, placing shotgun metagenomic information with regards to group level metabolic systems. Comparing the topological properties of the proteins in these systems with their plenitudes in various metagenomic tests and examining frameworks level topological highlights of microbiomes related with various host states enable us to obtain insight into variety in metabolic limit. This approach expands the metagenomic quality driven view by taking into account not just the arrangement of qualities display in a microbiome yet in addition the mind boggling web of interactions among these qualities and by treating the microbiome as a single “independent” natural framework. Computational frameworks biology strategies and complex system examinations have been connected broadly to consider microorganisms, and an assortment of methodologies have been produced to make genome-scale metabolic systems of different microbial species. These systems shape a rearrangements of the genuine underlying metabolic pathways and might be generally inaccurate and uproarious. Be that as it may, topology-based investigation of such systems has demonstrated capable for studying the attributes of single-species metabolic systems and their effect on different utilitarian and developmental properties, including scaling, metabolic usefulness and control, seclusion, vitality and mutant feasibility, hereditary and natural power, adjustment, and species interaction.