The Grinded reagent formed can then behave as a base or a nucleoli due to the partial charge between the carbonic and the alkyl group. The carbonic from the phenylalanine’s bromide act as a nucleoli and under go necrophilia addition reaction with the carbonyl group of the phenomenon forming an adduct. The adduct act as a strong base and propionate the proton from HCI with present of ether forming thermostatically (a tertiary alcohol) The reaction is illustrated below: In the presence of heat during refluxing the Grinded reagent, phenyl impurity is formed and can be isolated with petroleum ether by extraction.
The product can then be further purified through rationalizations method using hot spoilsport alcohol. This is then cooled to room temperature and facilitated with an ice bath. The purified thermostatically can then be vacuum filtered and dry. The reaction mechanism for the two steps described is as followed: The purified product obtained was then tested to confirm the successful synthesizing of thermostatically. Melting point value of 160-ICC was determine, which support the correct product synthesized.
Furthermore, all major functional groups were present in the IR taken for thermostatically indicating a successful experiment. Procedure: All glassware used in this experiment was oven dried and sterile. A Grinded reagent was produced by reacting -0. 15 g of magnesium metal, stir vane, 0. 80 ml of brokenness (0. 70 ml) and anhydrous ethyl ether (20. 0 ml) mixture in a 20-ml round-bottom flask (reflux apparatus). The apparatus was elevated from the hot plate and heated at ICC for 15 minutes. Brownish-gray solution was observed.
The remainder brokenness/ether mixture was added to the round bottom flask drop-wise with additional washing of -2. 0 ml of ethyl ether. Iodine (catalyst) was added to facilitate the reaction. Phenylalanine’s bromide was obtained upon cooling of the solution to room temperature. Phenomenon (1. 09 g) and ethyl ether (2. 0 ml) mixture was then reacted with the Grinded product for 15 minutes. Red solidified adduct was observed. Next HCI (6. 0 ml) was added drop-wise to the adduct; belayed of thermostatically and inorganic impurities was observed.
The mixture was then filtered using the revelatory funnel. The round-bottom flask was washed with additional ether (5. 0 ml) and re-extracted. Sodium sulfate was then added to dry the solution. Aqueous solution was then decanted into an Erlenmeyer flask and evaporated in a hot water bath (ICC) with air until oily solid was observed. Hot petroleum ether (3. 0 ml) was added drop-wise to dissolve the by-products and cooled to room temperature. Upon cooling, the crude was then vacuum filtered and collected.