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According to Hardin and Bertoni,1a centrosome functions as a primary microtubule organizing center during celldivision; this essentially means it is the point of origin for all microtubulesassociated thereof, as well as a source of securement2 so that themicrotubules can successfully move the chromosomes around as part of the cytoskeletalmitotic spindle.2 The mitotic spindle is controlled by the twocentrosomes present at the spindle poles.3 However, at the end ofeach cell cycle, each cell is left with just one centrosome, not two; thesecond centrosome is “formed” at the end of the “Centrosome Duplication Cycle,”a series of stages4 that involve the replication of the centrioles (structuresinside of the centrosome that are arranged at right angles to one another,5as seen in figure 1) prior to the centrosome itself being fully duplicated.Centrioles are important for cilia and flagellar purposes1, but alsoresponsible for the beginning centrosome duplication steps.

Despite “centriolesplitting” (separation of the two parent centrioles within the centrosome leftfrom the last cell cycle4) being the first step of the centrosomeduplication cycle, there is concern about the timing of this event; therefore,a centrosome is said to begin its visible duplication when a procentriole(essentially a daughter centriole) forms/is assembled near the end of each ofits parent centriole.4 Holland, Lan, and Cleveland, have determinedthat centriole duplication is reliant on the presence of Plk 4 (a type ofkinase that is useful in the regulation of centriole synthesis), and withoutproper amounts of it, the centriole duplication will not proceed; nevertheless,the group was unable to determine with certainty the specific point within thecell cycle that it helps promote centriole duplication, only that it mostcertainly does.7 

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