ABSTRACT Background: Infection caused by HCV is themajor cause of hepatic fibrosis.
Growing body evidences predict its role in extrahepatic manifestations that may ultimately trigger cardiovascular events.Objective: Present study will assessthe degree of hepatic fibrosis and intimal medial thickening of carotid artery(CIMT) in patients infected with hepatitis C (HCV). Study will also assess the correlation between hepatic fibrosis with CIMT in patientsinfected with HCV. Methodology:This cross sectional, descriptive study will be carried out in the out patientsdepartment of a hepatic clinic of a tertiary care hospital. A total of 60 HCVpatients of both sexes will be selected by convenient sampling technique alongwith 30 apparently healthy volunteers as control.
A signed informed consentwill be obtained from each participant. HCV infected patients with history of smoking,diabetes, hypertension; anemia will be exempted from the study. Data regarding biochemical parameters will be recorded in a questionnaire.Ten ml of blood will be sampled from each participant for the estimation ofRBS, CBC, liver function tests, HCV antibody and viral load. Stages of liverfibrosis will be evaluated by elastography and atherosclerosis of carotid arterywill be evaluated by CIMT by B-Mode ultrasonography by an expert radiologist ofthe department blind to the result of elastography. Data will be entered and analyzed by Statistical Package for SocialSciences Software (SPSS) Version 22.0.
Results will be depicted in tables andgraphs. Continuous variable will be presented as mean±SD. Frequencies andpercentages will be calculated for the categorical variables. A Chi-square testwill be performed for exploring the association between dependent (liverfibrosis) and independent variables (carotid intima media thickening). Ap-value of <0.05 will be considered as statistically significant.Key Words: HCV, Elestography,Carotid Intima Media Thickening